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Image Search Results
Journal: The Journal of Clinical Investigation
Article Title: Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice
doi: 10.1172/JCI41348
Figure Lengend Snippet: (A) Time course of MAP before and after inhibition of ganglionic transmission by hexamethonium (20 mg/kg i.p.) in Trpm4–/– (red, n = 9) and WT (black, n = 7) mice. (B and C) Averaged peak response of MAP to injection of hexamethonium (*P < 0.01) (B) or prazosin (1 mg/kg i.p.; WT, n = 7, Trpm4–/–, n = 9; *P < 0.05, C). (D) Plasma epinephrine and norepinephrine concentrations in WT and Trpm4–/– mice (n = 14 per genotype, *P < 0.01). (E) Catecholamine metabolite concentration in urine collected for 24 hours from WT (n = 15; for VMA, n = 6) and Trpm4–/– mice (n = 14; for VMA, n = 8; *P < 0.05).
Article Snippet: Acidified urine was analyzed by HPLC with ECD using commercially available
Techniques: Inhibition, Transmission Assay, Injection, Concentration Assay